文章摘要

药物联合宫腔镜取物钳在宫角妊娠中的治疗效果

作者: 1刘 铃铃, 1黄 守国
1 中南大学湘雅医学院附属海口医院妇产科,海口 570208
通讯: 刘 铃铃 Email: 710848598@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.02.018

摘要

目的:探讨氨甲蝶呤及米非司酮联合宫腔镜取物钳在宫角妊娠治疗中的效果。方法:对中南大学湘雅医学院附属海口医院2009年1月至2017年12月期间宫角妊娠患者进行回顾性分析,以采用氨甲蝶呤及米非司酮联合宫腔镜取物钳清宫者12例作为组1,以采用宫腔镜下行人工流产术者15例作为组2。比较两组患者手术时间、术中出血量、二次清宫率、住院时间、住院费用、血β-HCG恢复正常时间、恢复月经时间、术后经量减少及宫腔粘连等并发症发生率。结果:组1手术时间低于组2,差异有统计学意义(P<0.05);组1术中出血量少于组2,差异有统计学意义(P<0.05);组1二次清宫率低于组2,差异有统计学意义(P<0.05);组1住院时间高于组2,差异有统计学意义(P<0.05);组1与组2住院费用差异无统计学意义(P>0.05);组1血Β-HCG恢复正常时间较组2短,差异有统计学意义(P<0.05);组1恢复月经时间较组2短,差异有统计学意义(P<0.05);组1术后月经量减少比率较组2少,差异有统计学意义(P<0.05);两组术后宫腔粘连发生率差异无统计学意义(P<0.05)。结论:氨甲蝶呤及米非司酮联合宫腔镜取物钳在宫角妊娠治疗中较宫腔镜下直接行人工流产术更有效,术后恢复更快,对月经的影响更小,但住院时间较长,在临床推广需要更多样本的统计。
关键词: 宫角妊娠;宫腔镜;氨甲蝶呤;米非司酮;取物钳

Effect of drugs combined with forceps used in hysteroscopy on the treatment of cornual pregnancy

Authors: 1LIU Lingling, 1HUANG Shouguo
1 Department of Gynecology and Obstetrics, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China

CorrespondingAuthor:LIU Lingling Email: 710848598@qq.com

Abstract

Objective: To investigate the effect of methotrexate and mifepristone combined with forceps used in hysteroscopy in the treatment of patients with cornual pregnancy. Methods: A retrospective analysis was made on the patients with cornual pregnancy in our hospital from January 2009 to December 2017. Twelve patients who received methotrexate and mifepristone combined with forceps used in hysteroscopy were selected as the group 1; fifteen patients who received induced abortion in hysteroscopy were selected as group 2. The operation times, the amounts of bleeding in the operation, the rates of induced abortion twice, the times to be hospitalized, the hospitalization expenses, the times to recover normal β-HCG, the times of menstruous restoration and the postoperative complications were compared. Results: The operation time of group 1 is lower than that of group 2. There was statistical significance (P<0.05). The amount of bleeding in the operation of group 1 was less than that of group 2. There was statistical significance (P<0.05). The rate of induced abortion twice of group 1 was lower than that of group 2. There was statistical significance (P<0.05). The time to be hospitalized of group 1 was longer than that of group 2. There was statistical significance (P<0.05). The time to recover normal β-HCG of group 1 was shorter than that of group 2. There was statistical significance (P<0.05). The time of menstruous restoration of group 1 was shorter than that of group 2. There was statistical significance (P<0.05). There was no statistical significance in the hospitalization expenses. The rate of menstrual quantity decreases in group 1 is lower than that in group 2. There was no statistical significance in the rates of intrauterine adhesion. Conclusion: Methotrexate and mifepristone combined with forceps used in hysteroscopy are more effective than induced abortion in hysteroscopy in the treatment of cornual pregnancy. The time to recover is shorter. The effect on menstruation is even less. The disadvantage is that the time to be hospitalized was longer. More samples will be needed for clinical promotion.
Keywords: cornual pregnancy; hysteroscopy; methotrexate; mifepristone; forceps