文章摘要

儿童型双黄连口服液联合磷酸奥司他韦治疗流行性感冒的疗效

作者: 1高 育林, 1王 丽丽
1 西安航天总医院儿科,西安 710100
通讯: 高 育林 Email: 2154414013@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.02.012

摘要

目的:探讨儿童型双黄连口服液联合磷酸奥司他韦治疗小儿中轻度流行性感冒(以下简称流感)的价值。方法:选取西安航天总医院自2017年2月至2018年2月收治的流行性感冒患儿90例作为试验对象,按照随机数表法分成对照组(n=45)和观察组(n=45)。对照组口服磷酸奥司他韦治疗,观察组联合使用儿童型双黄连口服液和磷酸奥司他韦治疗,连续治疗7 d。比较两组患儿体温升高、咳嗽等症状恢复正常时间,免疫球蛋白水平变化,治疗总有效率和药物相关不良反应情况。结果:观察组治疗显效率为48.89%,远高于对照组的28.89%(χ2=3.878,P<0.05)。观察组发热、咳嗽、全身乏力等缓解时间均显著短于对照组(P<0.05)。治疗前两组免疫球蛋白A(IgA),IgM和IgG差异无统计学意义(P>0.05);治疗结束时观察组3项指标水平显著高于对照组(P<0.05)。观察组不良反应发生率为4.44%,对照组为2.22%,差异无统计学意义(χ2=0.557,P>0.05)。结论:儿童型双黄连口服液联合磷酸奥司他韦治疗中轻度流感患儿效果显著,可更好地改善患者的免疫功能,快速缓解临床症状,安全性满足要求,值得推广。
关键词: 流行性感冒;儿童;双黄连口服液;磷酸奥司他韦

Effect of children Shuanghuanglian mixture combined with oseltamivir phosphate in the treatment of influenza

Authors: 1GAO Yulin, 1WANG Lili
1 Department of Pediatrics, Xi 'an Aerospace General Hospital, Xi’an 710100, China

CorrespondingAuthor:GAO Yulin Email: 2154414013@qq.com

Abstract

Objective: To explore the value of children’s Shuanghuanglian mixture combined with oseltamivir phosphate in the treatment of pediatric influenza. Methods: Ninety children with influenza who were admitted to our hospital from February 2017 to February 2018 were selected as subjects. They were divided into two groups according to the principle of numerical randomization. Forty-five patients in the control group were treated with oral oseltamivir phosphate. Forty-five patients in the observation group were treated with children’s Shuanghuanglian mixture and oseltamivir phosphate for 7 days. The two groups of children with elevated body temperature, cough and time for returning to normal symptoms, changes in immunoglobulin levels, total treatment efficiency and drug-related adverse reactions. Results: The effective rate of observation group was 48.89%, which was much higher than that of the control group (28.89%, χ2=3.878, P<0.05). The remission time of patients with fever, cough and general malaise was significantly shorter than that of the patients in the control group (P<0.05). There was no significant difference in immunoglobulin A (IgA), IgM and IgG between the two groups before treatment, but at the end of treatment, the levels of these indicators in the observation group were significantly higher than those in the control group (P<0.05). The incidence of adverse reactions (4.44%) was no significant difference between the observation group (4.44%) and the control group (2.22%) (χ2=0.557, P>0.05). Conclusion: Shuanghuanglian mixture combined with oseltamivir phosphate is effective in the treatment of pediatric influenza. It can improve the immune function of the patients, relieve the clinical symptoms quickly, and meet the requirements of safety, which is worth popularizing.
Keywords: influenza; children; Shuanghuanglian mixture; oseltamivir phosphate