Objective: To explore the value of children’s Shuanghuanglian mixture combined with oseltamivir phosphate in the treatment of pediatric influenza. Methods: Ninety children with influenza who were admitted to our hospital from February 2017 to February 2018 were selected as subjects. They were divided into two groups according to the principle of numerical randomization. Forty-five patients in the control group were treated with oral oseltamivir phosphate. Forty-five patients in the observation group were treated with children’s Shuanghuanglian mixture and oseltamivir phosphate for 7 days. The two groups of children with elevated body temperature, cough and time for returning to normal symptoms, changes in immunoglobulin levels, total treatment efficiency and drug-related adverse reactions. Results: The effective rate of observation group was 48.89%, which was much higher than that of the control group (28.89%, χ2=3.878, P<0.05). The remission time of patients with fever, cough and general malaise was significantly shorter than that of the patients in the control group (P<0.05). There was no significant difference in immunoglobulin A (IgA), IgM and IgG between the two groups before treatment, but at the end of treatment, the levels of these indicators in the observation group were significantly higher than those in the control group (P<0.05). The incidence of adverse reactions (4.44%) was no significant difference between the observation group (4.44%) and the control group (2.22%) (χ2=0.557, P>0.05). Conclusion: Shuanghuanglian mixture combined with oseltamivir phosphate is effective in the treatment of pediatric influenza. It can improve the immune function of the patients, relieve the clinical symptoms quickly, and meet the requirements of safety, which is worth popularizing.