文章摘要

脓毒症患者血清IL-3的表达情况及其临床意义

作者: 1王 睿之, 1禹 茜, 2蔡 强, 3宋 琦, 1胡 军涛
1 广西医科大学第一附属医院重症医学科,南宁 530021
2 广西医科大学附属肿瘤医院麻醉科,南宁 530021
3 益都中心医院临床营养科,山东 潍坊 262500
通讯: 胡 军涛 Email: hujuntao80@126.com
DOI: 10.3978/j.issn.2095-6959.2020.02.010

摘要

目的:检测不同程度脓毒症患者血清白介素-3(interleukin-3,IL-3)的表达情况,并探究其与疾病的相关性。方法:纳入2017年12月至2018年12月符合条件的脓毒症病例组100例,分为非休克组(n=69)和休克组(n=31),存活组(n=79)和死亡组(n=21)。并纳入同时期健康体检人群50例作为对照组。收集患者的血尿样本检测包括IL-3等相关生化指标,同时记录患者急性病生理学和长期健康评价II(acute physiology and chronic health evaluation,APACHE II)评分以及序贯器官衰竭评分(sequential organ failure assessment,SOFA),作为评估疾病严重程度的指标。结果:脓毒症病例组血清IL-3水平显著高于健康对照组(P<0.01),休克组血清IL-3水平高于非休克组(P<0.01),死亡组血清IL-3水平高于存活组(P<0.01);脓毒症患者血清IL-3水平与APACHE II评分(r=0.67,P=0.02)及SOFA(r=0.59,P=0.03)呈正相关联系;脓毒症患者血清IL-3水平是患者发生死亡事件的独立危险因素(P=0.03);IL-3水平判断脓毒症死亡预后的ROC曲线下面积为0.88,灵敏度为0.86,特异度为0.72(P=0.03)。结论:脓毒症患者血清IL-3水平升高,且与疾病严重程度具有相关性,可用于评估脓毒症患者预后。
关键词: 脓毒症;休克;死亡;白介素-3;疾病严重程度

Expression of interleukin-3 in patients with sepsis and its clinical significance

Authors: 1WANG Ruizhi, 1YU Qian, 2CAI Qiang, 3SONG Qi, 1HU Juntao
1 Intensive Care Unit, First Affiliated Hospital of Guangxi Medical University, Nanjing 530021, China
2 Department of Anesthesiology, Tumor Hospital, Guangxi Medical University, Nanjing 530021, China
3 Department of Clinical Nutrition, Yidu Central Hospital, Weifang Shandong 262500, China

CorrespondingAuthor:HU Juntao Email: hujuntao80@126.com

Abstract

Objective: To detect the serum levels of interleukin-3 (IL-3) in patients with sepsis and its clinical significance. Methods: One hundred cases of sepsis in our hospital from December 2017 to December 2018 were divided into a non-shock group (n=69), a shock group (n=31), a survival group (n=79), and death group (n=21). Fifty healthy people in the same period were enrolled as the control group. Blood and urine samples were collected for the measurement of IL-3 and other related biochemical indicators. Acute physiology and chronic health evaluation II (APACHE II) and sequential organ failure assessment (SOFA) were recorded as indicators to assess the severity of the disease. Results: Serum levels of IL-3 in sepsis group were significantly higher than those in healthy control group (P<0.01), while serum levels of IL-3 in shock group were higher than those in non-shock group (P<0.01), and serum levels of IL-3 in death group were higher than those in survival group (P<0.01). Serum levels of IL-3 was positively correlated with APACHE II score (r=0.67, P=0.02) and SOFA score (r=0.59, P=0.03). Serum levels of IL-3 was an independent risk factor for death events in sepsis patients (P=0.03); the ROC curve area under which IL-3 level judged the prognosis of sepsis death was 0.88, sensitivity was 0.86, specificity was 0.72 (P=0.03). Conclusion: Serum levels of IL-3 in sepsis patients are elevated and correlated with the severity of the disease. It can be used to evaluate the prognosis of sepsis.
Keywords: sepsis; shock; death; interleukin-3; severity of the disease