文章摘要

结肠癌病理T分期、N分期与肿瘤沉积的相关性

作者: 1,2王 晨, 1李 绍东, 1,2孟 闫凯, 1李 江山, 1高 晶晶, 3曹 楷, 4姚 立彬, 3崔 莹莹
1 徐州医科大学附属医院影像科,江苏 徐州 221002
2 徐州医科大学影像学院,江苏 徐州 221002
3 徐州医科大学附属医院病理科,江苏 徐州 221002
4 徐州医科大学附属医院普外科,江苏 徐州 221002
通讯: 崔 莹莹 Email: cui-yingying@163.com
DOI: 10.3978/j.issn.2095-6959.2020.02.008

摘要

目的:探讨结肠癌患者肿瘤沉积的发生率与病理T分期、N分期的相关性。方法:回顾性分析2017—2018年于徐州医科大学附属医院就诊的经手术病理证实的257例结肠癌患者的临床病理资料。按照第8版AJCC结直肠癌分期指南将患者分为T2,T3,T4期组;N0,N+(N1+N2)期组;以及肿瘤沉积阳性、阴性组。肿瘤沉积与T分期、N分期的相关性分析采用行×列表卡方检验,组间比较采用卡方分割法。结果:T2,T3,T4期分别有2例(5.6%),30例(14.6%),10例(66.7%)患者发生肿瘤沉积。不同T分期患者肿瘤沉积的发生率差异有统计学意义(χ2=31.327,P<0.05)。组间比较T2期、T3期结肠癌患者肿瘤沉积的发生率均低于T4期,差异具有统计学意义(χ2=21.976,25.606,均P<0.016);T2期,T3期结肠癌患者间肿瘤沉积发生率无明显统计学差异(P=0.141)。N0,N+期结肠癌分别有7例(4.2%),35例(38.0%)例患者出现肿瘤沉积,卡方检验比较差异具有统计学意义(χ2=49.360,P<0.001);N1,N2期亚组分析结果表明差异无统计学意义(χ2=3.091,P=0.079)。结论:T4期、N+期结肠癌患者出现肿瘤沉积的风险更高,肿瘤沉积与T分期、N分期的增高具有相关性。
关键词: 结肠癌;肿瘤沉积;病理T,N分期;淋巴结

Correlation of pathological T and N staging with tumor deposits in colon cancer

Authors: 1,2WANG Chen, 1LI Shaodong, 1,2MENG Yankai, 1LI Jiangshan, 1GAO Jingjing, 3CAO Kai, 4YAO Libin, 3CUI Yingying
1 Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Jiangsu 221002, China
2 School of Imaging, Xuzhou Medical University, Xuzhou Jiangsu 221002, China
3 Department of Pathology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Jiangsu 221002, China
4 Department of General Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou Jiangsu 221002, China

CorrespondingAuthor:CUI Yingying Email: cui-yingying@163.com

Abstract

Objective: To investigate the association between pathological TN staging and tumor deposits in colon cancer. Methods: Pathological data of 257 colon cancer cases from 2017 to 2018 was retrospectively analyzed. According to the 8th edition of the American Joint Committee on Cancer (AJCC) staging manual, all patients were devided into T2, T3 and T4 groups, N0, N+(N1+N2) groups, tumor deposits positive and negative group. R×C chi-suqare test was performed to analyze the correlations of T and N stage with tumor deposits. Using the chi-square decomposition to further pairwise comparison. Results: Of which, 2 cases (5.6%) with tumor deposits positive in T2 group, 30 cases (14.6%) in T3 group, 10 cases (66.7%) in T4 group. Chi-square test showed that tumor deposits during three groups were statistically different (χ2=31.327, P<0.05 respectively). Pairwise comparison showed that the incidence of tumor deposits in T2 and T3 groups was lower than those of the T4 group, the difference with statistical significance (χ2=21.976, 25.606, respectively and P<0.016, P<0.016 respectively). Nevertheless, there was no significant difference between T2 and T3 groups (P=0.141). In the N staging, 7 cases (4.2%) with tumor deposits in N0 group, 21 cases(22.8%) in N1 group, 14 cases (15.2%) in N2 group. Chi-square test showed significant different between N0 and N+ groups (χ2=49.360, P<0.001 respectively). Subgroup analysis was carried by N+ group, the difference between N1 and N2 groups was not statistically significant (χ2=3.091, P=0.079). Conclusion: T4 and N+ staging colon cancer patients have the higher risk of tumor deposits than other stages, tumor deposits is associated with elevating pathological T and N staging in colon cancer.
Keywords: colon cancer; tumor deposits; pathological T N staging; lymph node