组织因子途径抑制物与心血管疾病的关系
| 作者: |
1杨六平,
1李嘉舒,
1傅羽
1 哈尔滨医科大学附属第一医院心血管内科，哈尔滨 150001 |
| 通讯: |
傅羽
Email: fuyu198010@yahoo.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.10.026 |
| 基金: | 国家自然科学基金 (81200143，81200235)；黑龙江省自然科学基金 (QC2012C015)；哈尔滨医科大学附属第一医院基金 (2015B002)。 |
摘要
组织因子途径抑制物(tissue factor pathway inhibitor，TFPI)是调节组织因子介导的外源性凝血途径的主要抑制物。大量研究数据表明，组织因子途径抑制物与心血管疾病的发生发展密切相关。目前已发现其可通过抗凝、抗炎、抑制内皮及平滑肌细胞增殖、抗血管重塑等机制阻止心血管疾病的发生和发展。
关键词：
组织因子途径抑制物；组织因子；心血管疾病；外源性凝血途径
Relationship between tissue factor pathway inhibitor and cardiovascular diseases
CorrespondingAuthor: FU Yu Email: fuyu198010@yahoo.com
DOI: 10.3978/j.issn.2095-6959.2019.10.026
Foundation: This work was supported by the National Natural Science Foundation (81200143, 81200235)
Abstract
Tissue factor pathway inhibitor (TFPI) is the main inhibitor regulating tissue factor-mediated exogenous coagulation pathway. A large number of research data indicate that TFPI is closely related to the occurrence and development of cardiovascular diseases. It has been found to inhibit cardiovascular disease through anticoagulant, anti-inflammatory, inhibition of endothelial and smooth muscle cell proliferation, and anti-vascular remodeling.
Keywords：
tissue factor pathway inhibitor; tissue factor; cardiovascular diseases; exogenous coagulation pathway