文章摘要

胃血管球瘤2例的临床病理特征及文献复习

作者: 1胡 飘飘, 1徐 晓艳
1 内蒙古医科大学病理科,呼和浩特 010059
通讯: 徐 晓艳 Email: xxy_patho@163.com
DOI: 10.3978/j.issn.2095-6959.2019.09.039

摘要

对2例胃血管球瘤进行胃镜检查、HE染色及免疫组织化学染色、PAS染色,观察其临床表现、镜下形态以及免疫组织化学特点,并复习相关文献。1例为男性患者,胃镜检查显示胃黏膜表面1个直径约2 cm的圆形隆起,表面光滑;另1例为女性患者,胃镜检查显示胃黏膜表面1个直径约3 cm的圆形隆起,表面光滑。2例患者入院前均有上腹部疼痛症状。光镜下均表现为肿瘤组织呈结节分叶状,被平滑肌细胞分隔包绕。肿瘤细胞大小一致,呈圆形或卵圆形,围绕薄壁的血管或血窦周围排列,呈血管外皮瘤样或实性巢团状,肿瘤细胞胞界清楚,呈多边形,细胞核圆形或卵圆形,核仁可见。免疫组织化学波形蛋白(Vimentin)、平滑肌肌动蛋白(SMA),钙调节蛋白(Calponin)和IV型胶原均(+),余CD117,DOG-1,CD34,广谱细胞角蛋白(CKAE1/AE3),Syn,S100均阴性。PAS染色显示为:2例胃血管球瘤均见到间质在细胞间呈现细枝状分布,部分区域呈鸡爪样改变。胃血管球瘤绝大多数为良性肿瘤,需要靠组织病理及免疫组织化学才能确诊。
关键词: 胃;血管球瘤;免疫组织化学

Clinicopathological features of 2 cases of gastric glomus tumor and literature review

Authors: 1HU Piaopiao, 1XU Xiaoyan
1 Department of Pathology, Inner Mongolia Medical University, Hohhot 010059, China

CorrespondingAuthor:XU Xiaoyan Email: xxy_patho@163.com

Abstract

This article aimed to investigate the clinical manifestations, gross morphology, microscopic morphology and immunohistochemical features of gastric glomus tumors. Two cases of gastric glomus tumors were examined by gastroscopy, HE staining and immunohistochemistry staining, special dyeing. The clinical manifestations, microscopic morphology and immunohistochemical characteristics were observed, and related literatures were reviewed. One male of 2 patients showed a circular bulge with a diameter of about 2 cm on the surface of the gastric mucosa, the surface was smooth and a female, gastroscopic examination showed a circular bulge with a diameter of about 3 cm on the surface of the gastric mucosa, the surface was smooth. Both patients had symptoms of upper abdominal pain before admission. Under light microscopy, the tumor tissue showed nodular lobular shape and was surrounded by smooth muscle cells. The tumor cells are uniform in size and round or oval. They are arranged around the thin-walled blood vessels or around the sinusoids. They are angiocarcinoma-like or solid nest-like, and the nucleus of the tumor is round. Immunohistochemical Vimentin, SMA, Calponin and type IV collagen were all positive, and the remaining CD117, DOG-1, CD34, CKAE1/AE3, Syn and S100 were negative. PAS staining showed that both cases of gastric glomus tumors, the mesenchyme showed a fine branch-like distribution between cells, and some areas showed chicken-like changes. Most of the glomus tumors of the stomach are benign tumors, which need to be confirmed by histopathology and immunohistochemistry.
Keywords: stomach; glomus tumor; immunohistochemistry