文章摘要

自噬在神经退行性疾病中的调控作用

作者: 1徐 宏睿, 1曾 常茜
1 大连大学医学院医学检验系,辽宁 大连 116611
通讯: 曾 常茜 Email: zengchangqian@163.com
DOI: 10.3978/j.issn.2095-6959.2019.09.037

摘要

自噬过程受到一系列复杂信号分子的调控。基础水平的自噬在清除异常积聚的蛋白质、受损的细胞器、维持细胞自身内环境的稳定和细胞生存中扮演着重要角色。自噬水平的上调或者降低与神经退行性疾病的发生发展有密切联系。调节自噬可以有效清除神经细胞中异常折叠积聚的蛋白质,从而缓解疾病进展。随着近几年对自噬现象和机制研究的不断深入,促进或者逆转自噬可能是一种治疗神经退行性疾病的有效策略和途径。
关键词: 自噬;神经退行性疾病;帕金森病;阿尔茨海默病;肌萎缩性侧索硬化症;亨廷顿氏舞蹈病;癫痫

Regulation of autophagy in neurodegenerative diseases

Authors: 1XU Hongrui, 1ZENG Changqian
1 Department of Medical Laboratory, Medical College of Dalian University, Dalian Liaoning 116611, China

CorrespondingAuthor:ZENG Changqian Email: zengchangqian@163.com

Abstract

The autophagy is regulated by a series of complicated signaling molecules. The autophagy of basic levels play an important role in clearing abnormally accumulated proteins and damaged organelles, maintaining the stability of the cell's own environment and cell survival. The up-regulation or down-regulation of autophagy levels is related to the development of neurodegenerative diseases closely. Abnormally accumulated proteins in nerve cells can be eliminated effectively by regulating autophagy, thereby the disease is remitted. With the deep research on autophagy and mechanism in recent years, promotion or reversion on autophagy may be an effective strategy in therapy for neurodegenerative diseases.
Keywords: autophagy; neurodegenerative disease; Parkinson’s disease; Alzheimer’s disease; amyotrophic lateral sclerosis; Huntington’s disease; epilepsia