1 复旦大学附属肿瘤医院头颈外科，上海 200032
2 复旦大学上海医学院肿瘤学系，上海 200032
Expressions of CD90 and Tenascin-C in thyroid papillary carcinoma and their relation with clinicopathological features
This work was supported by the National Natural Science Foundation (81772854) and Shanghai Natural Science Foundation (19ZR1410900), China.
Objective: To study the expression levels of CD90 and Tenascin-C in papillary thyroid carcinoma and their relationship with clinicopathological features. Methods: A total of 70 cases of papillary thyroid carcinoma tissues were collected from the Department of Pathology of our hospital from Jan 2016 to December 2018. At the same time, 70 normal thyroid tissues were selected as controls. Immunohistochemistry and immunofluorescence were used to detect CD90 and Tenascin-C in cancer and adjacent tissues. The expression level of CD90 and Tenascin-C protein were analyzed with their relationship with clinical features. Results: The positive expression rates of CD90 and Tenascin-C in cancer tissues were 60.30% and 62.55%, respectively, which were higher than 6.62% and 6.87% in adjacent tissues, and the difference was statistically significant (P<0.05). The expressions of CD90, Tenascin-C were not significantly associated with age, gender, and tumor size in patients with papillary thyroid carcinoma (P>0.05), but were associated with lymph node metastasis (P<0.05). CD90 + Tenascin-C double positive was associated with tumor multifocal, extra-glandular invasion and lymph node metastasis (P<0.05). Immunofluorescence confirmed the coexistence of Tenascin-C protein and tumor-associated fibroblast marker CD90. Conclusion: CD90 and Tenascin-C were highly expressed in papillary thyroid carcinoma, which was related to the clinicopathological features of patients.
CD90; tenascin-C; tumor-associated fibroblast; papillary thyroid carcinoma; clinicopathological features.