文章摘要

转化生长因子β1 与心血管疾病的研究进展

作者: 1王 正辉, 1张 国辉
1 江苏大学附属人民医院心血管内科,江苏 镇江 212002
通讯: 张 国辉 Email: 13338812776@189.cn
DOI: 10.3978/j.issn.2095-6959.2019.02.029
基金: 镇江市科技局基金 (SH2015025)。

摘要

转化生长因子β1(transforming growth factor β1,TGF-β1)是TGF-β超家族成员之一,是调节细胞生长、促进组织纤维化的重要细胞因子。研究发现TGF-β1多在血管平滑肌细胞、内皮细胞、造血细胞和巨噬细胞中表达,在高血压、冠心病、心力衰竭、心房纤颤等众多心血管疾病中起至关重要的作用。
关键词: 转化生长因子β1;高血压;冠心病;心力衰竭;心房纤颤;进展

Research progress of transforming growth factor β1 in cardiovascular diseases

Authors: 1WANG Zhenghui, 1ZHANG Guohui
1 Department of Cardiology, People’s Hospital of Jiangsu University, Zhenjiang Jiangsu 212002, China

CorrespondingAuthor:ZHANG Guohui Email: 13338812776@189.cn

Foundation: This work was supported by the Zhenjiang Science and Technology Bureau Foundation, China (SH2015025).

Abstract

Transforming growth factor β1 (TGF-β1) is a member of the TGF-β superfamily and is an important cytokine that regulates cell growth and promotes tissue fibrosis. It has been found that TGF-β1 is expressed in vascular smooth muscle cells, endothelial cells, hematopoietic and macrophages cells, and plays a very important role in many cardiovascular diseases such as hypertension, coronary heart disease, heart failure and atrial fibrillation.
Keywords: transforming growth factor β1; hypertension; coronary heart disease; heart failure; atrial fibrillation; progress