腺苷酸环化酶的研究进展
| 作者: |
1杨琰茗,
1杨雅清,
1宋杲,
1杨为民,
1翁稚颖
1 昆明医科大学药学院暨云南省天然药物药理重点实验室，昆明 650500 |
| 通讯: |
翁稚颖
Email: weng_zy@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.02.026 |
| 基金: | 国家自然科学基金 (81860012)；云南省科学基金 (2017FE467-023)；滇美分子药物联合研究中心 (2015ID001)。 |
摘要
腺苷酸环化酶(adenyl cyclase，AC)是G蛋白偶联受体(G protein-coupled receptor，GPCR)下游的关键信号分子，通过调节环腺苷-3',5'-一磷酸(cAMP)的合成调控多种细胞功能，从而参与机体的多种病理生理过程。哺乳动物细胞表达了9个跨膜AC亚型(AC1~9，mACs)和1个可溶性AC(sAC，也称为AC10)，各亚型在不同组织细胞膜微筏(脂筏)中存在差异性表达，由于不同亚型间具有非特异的交叉协同性或拮抗性，各亚型的非选择性激活/抑制会带来很多潜在的不良反应，因此目前还缺乏特异性的激动剂和抑制剂。认识和了解AC各亚型的研究现状，对进一步研究各亚型特异性激动剂/抑制剂及未来靶向药物的研究具有重要意义。
关键词：
腺苷酸环化酶；亚型；特异性
Research progress of adenylate cyclase
CorrespondingAuthor: WENG Zhiying Email: weng_zy@sina.com
DOI: 10.3978/j.issn.2095-6959.2019.02.026
Foundation: This work was supported by the National Natural Science Foundation (81860012), Yunnan Provincial Science and Technology Department (2017FE467-023)
Abstract
Adenyl cyclase (AC), as a key downstream signaling factor of G protein -coupled receptor (GPCR), is involved in a variety of potential physiological and pathological processes by adjusting the cyclic adenosine-3', 5'-monophosphate (cAMP). So far, nine membrane isoforms (AC1–9) and a soluble adenyl cyclase (sAC) have been cloned. They are expressed in different organs, and have different physiological functions. Non-selective activation/inhibition has many potential side effects. In this article we will summarize the current research of AC isoforms. Research on specific agonists/inhibitors and potential targeted drugs is of great significance.
Keywords：
adenyl cyclase; isoforms; specificity