1 武汉大学人民医院神内一科，武汉 430060
|| 武汉大学人民医院护理科研支持项目 (HL2018ZC-33)。
目的：观察思密达外敷联合重组人表皮生长因子治疗宫颈癌放射治疗所导致的会阴部II级及以上放射性皮炎的效果。方法：将70例宫颈癌行放射治疗的患者出现II级及以上会阴部放射性皮炎者随机分为观察和对照两组。对照组采用常规重组人表皮生长因子涂擦治疗；观察组在常规护理基础上加思密达外敷，治疗结束后比较两组皮炎的康复情况、愈合时间和疼痛程度。结果：观察组患者疗效(88.9%)显著高于对照组(59.5%)，会阴部放射性皮炎愈合时间(6.54±4.65) d短于对照组(10.80±5.60) d，疼痛程度显著低于对照组，差异均有统计学意义(P<0.05)。结论：对于放射治疗所致的宫颈癌患者会阴部皮炎，使用思密达(蒙脱石散)联合重组人表皮生长因子能够有效地提升治疗效果，缩短创面愈合时间，降低患者疼痛感，且材料便宜、易得，具有较高的普适性。
Therapeutic effect of smecta combined with recombinant human epidermal growth factor on the treatment of radiotherapy
This work was supported by Nursing Research Support Project of Renmin Hospital of Wuhan University, China (HL2018ZC-33).
Objective: To observe the effect of external application of smecta combined with recombinant human epidermal growth factor on the treatment of radiation dermatitis of grade II or above in the perineum caused by radiation therapy of cervical cancer. Methods: Seventy patients with cervical cancer having grade II or higher perirradial radiodermatitis after radiation therapy were randomly divided into an observation group and a control group. The control group was treated with conventional recombinant human epidermal growth factor, the observation group was treated with Smecta on the basis of conventional care, and the dermatitis recovery, average recovery time, and pain degree were compared between the two groups after treatment. Results: The therapeutic effect of the observation group (88.9%) was significant higher than the control group (59.5%), the healing time [(6.54±4.65) d] was shorter than the control group [(10.80±5.60) d], the pain degree was lower than that of the control group, the differences were statistically significant (P<0.05). Conclusion: For perineal dermatitis in patients with cervical cancer due to radiotherapy, the use of smecta (montmorillonite powder) combined with recombinant human epidermal growth factor can effectively improve the therapeutic effect, shorten the healing time, reduce the pain of patients, and the medical is cheap and easy bought.
cervical cancer; radioactive dermatitis; smecta; external application