文章摘要

慢性阻塞性肺疾病患者呼出气一氧化氮不同水平与炎症表型的相关性

作者: 1文 亚坤, 1林 蕊艳, 1杨 晶晶
1 首都医科大学附属北京潞河医院呼吸科,北京 101149
通讯: 杨 晶晶 Email: 3237199649@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.02.011

摘要

目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者呼出气一氧化氮(FeNO)不同水平与炎症表型的相关性。方法:选取2016年1月至2018年6月首都医科大学附属北京潞河医院呼吸内科接诊的北京市通州区153例稳定期COPD患者为研究对象,所有患者完善FeNO水平检测、肺功能测定、血清炎症反应标志物检测和诱导痰检测。分析FeNO水平与COPD临床特征、炎症表型的关系。结果:随着FeNO水平升高,COPD患者肺功能降低、呼吸困难症状加重、炎症反应指标升高(P<0.05)。不同FeNO水平COPD炎症表型分布差异有统计学意义(P<0.05),嗜酸性粒细胞性COPD患者FeNO水平高于非嗜酸性粒细胞性COPD患者[(35.61± 7.18) ppb v s 23.47±3.02) ppb,P<0.05]。FeNO与嗜酸性粒细胞计数、炎性因子水平呈正相关(P<0.05),与肺功能呈负相关(P<0.05)。结论:嗜酸性粒细胞性COPD患者FeNO水平偏高,FeNO是反应COPD气道炎症反应的敏感指标。
关键词: 慢性阻塞性肺疾病;呼出气一氧化氮;炎症表型;嗜酸性粒细胞

Correlation between different levels of fractional exhaled nitric oxide and inflammatory phenotype in COPD patients

Authors: 1WEN Yakun, 1LIN Ruiyan, 1YANG Jingjing
1 Department of Respiration, Beijing Luhe Hospital, Affiliated to Capital of Medical University, Beijing 101149, China

CorrespondingAuthor:YANG Jingjing Email: 3237199649@qq.com

Abstract

Objective: To investigate the correlation between different levels of fractional exhaled nitric oxide (FeNO) and inflammatory phenotypes in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 153 COPD patients admitted to the department of respiratory of Beijing Luhe Hospital Affiliated to Capital Medical University in Beijing Tongzhou district from January 2016 to June 2018 were selected as the study subjects. All patients improved FeNO level detection, lung function detection, serum inflammatory reaction markers detection and induced sputum test. The relationship between FeNO level and clinical features and inflammatory phenotypes of COPD was analyzed. Results: With the increase of FeNO level, the lung function decreased, dyspnea symptoms increased, and inflammatory response indicators increased of COPD patients (P<0.05). The inflammatory phenotypes of COPD at different FeNO levels was statistically significant (P<0.05). FeNO levels in eosinophilic COPD patients were higher than those in non-eosinophilic COPD patients[(35.61±7.18) ppb vs (23.47±3.02) ppb, P<0.05]. FeNO was positively correlated with eosinophil count and inflammatory factor levels (P<0.05), and negatively correlated with lung function (P<0.05). Conclusion: FeNO level is high in eosinophilic granulocyte COPD patients in Beijing. FeNO is a sensitive indicator of airway inflammation in COPD.
Keywords: chronic obstructive pulmonary disease; fractional exhaled nitric oxide; inflammatory phenotype; eosinophils