文章摘要

中重度阻塞性睡眠呼吸暂停低通气综合征患者血清神经肽Y和人生长激素释放多肽变化与认知功能的关系

作者: 1潘 峰, 2唐 蕾, 1孟 雄
1 中国人民解放军陆军第958医院呼吸内科,重庆 400020
2 中国人民解放军陆军第958医院空勤科,重庆 400020
通讯: 孟 雄 Email: mengxiong198402@163.com
DOI: 10.3978/j.issn.2095-6959.2019.02.010

摘要

目的:探讨中重度阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome, OSAHS)患者血清神经肽Y(neuropept ide Y,NPY)、人生长激素释放多肽变化与认知功能的关系。方法:选择110例OSAHS患者作为试验组,其中中度组30例,重度组80例;另选择同时期40例单纯鼾症患者作为对照组。比较各组血清NPY和人生长激素释放多肽水平,记录各组MoCA和MMSE评分以评估患者的认知功能,并分析NPY,人生长激素释放多肽(Ghrel in)与认知功能的相关性。结果:试验组血清NPY水平均显著高于对照组,差异具有统计学意义(P<0.05);重度组NPY水平高于中度组(P<0.05)。试验组血清Ghrelin水平均显著低于对照组,差异具有统计学意义(P<0.05);重度组低于中度组(P<0.05)。三组MoCA与MMSE总评分差异具有统计学意义(P<0.05);其中重度组MoCA与MMSE总评分明显低于对照组和中度组(P<0.05)。患者MoCA总评分与血清NPY水平呈负相关(r=−0.562,P<0.05),与血清Ghrel in水平呈正相关(r=0.469, P<0.05);MMSE总评分与血清NPY水平呈负相关(r=−0.431,P<0.05),与血清Ghrelin水平呈正相关(r=0.386,P<0.05)。结论:OSAHS可引起患者血清NPY和Ghrelin水平变化,对患者的认知功能有一定损害,血清肽类物质的改变与患者认知功能相关。
关键词: 阻塞性睡眠呼吸暂停低通气综合征;神经肽Y;人生长激素释放多肽;蒙特利尔认知评估表;认知 功能

Relationship between changes of serum neuropeptide Y, ghrelin and cognitive function in patients with moderate to severe obstructive sleep apnea hypopnea syndrome

Authors: 1PAN Feng, 2TANG Lei, 1MENG Xiong
1 Department of Respiratory Medicine, 958 Hospital of PLA, Chongqing 400020, China
2 Air Service Department, 958 Hospital of PLA, Chongqing 400020, China

CorrespondingAuthor:MENG Xiong Email: mengxiong198402@163.com

Abstract

Objective: To investigate the relationship between changes of serum neuropeptide Y (NPY), ghrelin and cognitive function in patients with moderate to severe obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: A total of 110 patients with OSAHS were divided into a moderate group (n=30) and a severe group (n=80). Forty snoring patients were selected as a control group. The levels of serum neuropeptide Y and ghrelin were compared between the groups. The MoCA and MMSE scores of each group were recorded to evaluate the cognitive function. The correlation between NPY, ghrelin and cognitive function was analyzed. Results: Serum NPY level of OSAHS patients was significantly higher than that in the control group (P<0.05). Meanwhile, the NPY level in the severe group was higher than that in the moderate group (P<0.05). The ghrelin level of OSAHS patients was significantly lower than that in the control group, and the difference was statistically significant (P<0.05). The ghrelin level in the severe group was lower than that in the moderate group (P<0.05). The MoCA and MMSE scores of three groups were significantly different (P<0.05). The MoCA and MMSE scores of the severe group were significantly lower than those of the control group and the moderate group (P<0.05). The MoCA score of patients was negatively correlated with serum NPY level (r=−0.562, P<0.05), and positively correlated with serum ghrelin level (r=0.469, P<0.05). The MMSE score was negatively correlated with serum NPY level (r=–0.431, P<0.05), positively correlated with serum ghrelin level (r=0.386, P<0.05). Conclusion: OSAHS can cause changes of serum NPY and ghrelin levels. OSAHS is harmful to the cognitive function of the patients. The changes of serum peptides are related to cognitive function.
Keywords: obstructive sleep apnea-hypopnea syndrome; neuropeptide Y; ghrelin; Montreal Cognitive Assessment; cognitive function