文章摘要

JAK2-STAT3 信号通路在缺血性疾病的研究进展

作者: 1彭 长铁, 1邓 礼明, 1熊 国祚, 1罗 东阳
1 南华大学附属第二医院血管外科,湖南 衡阳 421001
通讯: 邓 礼明 Email: Dengliming83@163.com
熊 国祚 Email: 55752528@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.01.025
基金: 湖南省临床医疗技术创新引导计划项目(2017SK50210)。

摘要

JAK2-STAT3信号途径是参与机体的分化、侵袭、代谢、血管再生的重要信号途径,多种因子及药物可通过激活此通路促进血管内皮细胞新生,改善缺血,而广泛用于基础实验及缺血性疾病的研究, 本文将综述近年来JAK2-STAT3信号途径在心、脑、外周血管及其他缺血性疾病等方面进行的研究。
关键词: JAK2-STAT3通路;血管再生;缺血性疾病

Research progress of JAK2-STAT3 signaling pathway in ischemic diseases

Authors: 1PENG Changtie, 1DENG Liming, 1XIONG Guozuo, 1LUO Dongyang
1 Department of Vascular Surgery, Second Affiliated Hospital, University of South China, Hengyang Hunan 421001, China

CorrespondingAuthor:DENG Liming Email: Dengliming83@163.com

Foundation: This work was supported by the Hunan Provincial Clinical Medical Technology Innovation Guidance Project, China (2017SK50210).

Abstract

JAK2-STAT3 is an important signaling pathway which is involved in the differentiation, invasion, metabolism and angiogenesis in human body. A variety of factors and drugs are widely used in the research on ischemic diseases by activating this pathway to promote vascular endothelial cell neovascularization and to improve ischemia symptoms. This article reviews recent studies on the roles of JAK2-STAT3 signaling pathway in heart, brain, peripheral blood vessels and other ischemic diseases.
Keywords: JAK2-STAT3 pathway; angiogenesis; ischemic disease