3- 羧-4- 甲-5- 丙基呋喃戊酮酸与脂代谢研究进展
| 作者: |
1戴嘉融,
1于雪梅
1 上海交通大学附属第六人民医院南院内分泌代谢科，上海 201499 |
| 通讯: |
于雪梅
Email: xuemeiyu12@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.10.027 |
| 基金: | 上海市医学重点专科建设计划 (ZK2015A02)。 |
摘要
3-羧-4-甲-5-丙基呋喃戊酮酸(3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid，CMPF)作为内源性呋喃脂肪酸的代谢产物，其血清水平与鱼油的摄入有明确的关系。近期研究发现血清CMPF水平在糖尿病患者中升高，CMPF能抑制胰岛β细胞释放胰岛素。CMPF使细胞代谢从葡萄糖利用转而向更多的脂肪酸的利用。最新研究表明CMPF能改善肥胖小鼠的胰岛素敏感性，并促进肝脂肪酸β氧化，缓解由高脂饮食诱导的早期脂肪肝进程。在机制上，CMPF可在短期内抑制乙酰辅酶A羧化酶(acetyl CoA carboxylase，ACC)活性，也可长期抑制SREBP1和ACC1/2基因表达，从而抑制脂质的合成以及促进分解。因此，探索CMPF与脂代谢的关系，可以进一步为肥胖、脂肪肝的预防与治疗提供新的思路。
关键词：
3-羧-4-甲-5-丙基呋喃戊酮酸；脂肪肝；三酰甘油；胰岛素抵抗；肥胖
3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid and lipid metabolism
CorrespondingAuthor: YU Xuemei Email: xuemeiyu12@163.com
DOI: 10.3978/j.issn.2095-6959.2018.10.027
Foundation: This work was supported by Key Specialty of Diabetes in Shanghai, China (ZK2015A02).
Abstract
3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), an endogenous metabolites of furan fatty acids, has a significant association linked to fish oil intake in human. Several researches showed that circulating levels of CMPF increase in individuals with diabetes mellitus, and CMPF impairs insulin secretion. However, a recent study showed that the administration of CMPF to mice before or after high-fat diet feeding improved insulin sensitivity, increased beta-oxidation, and ameliorated steatosis. Mechanistically, CMPF acutely inhibits ACC activity and induces long-term loss of SREBP1 and ACC1/2 expression, which results in reduction of lipid synthesis as well as promotion of lipid utilization. Therefore, further exploration of the relationship between CMPF and lipid metabolism will give a new direction in treating obesity and fatty liver.
Keywords：
3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid; fatty liver; triglycerides; insulin resistance; obesity