非编码RNA 在炎症性肠病中的研究进展
| 作者: |
1姚俊,
1许亚平,
1石岩
1 江苏大学附属人民医院，江苏 镇江 212002 |
| 通讯: |
石岩
Email: sysh2014@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.09.028 |
| 基金: | 国家自然科学基金青年项目 (81700494)；江苏省重点研发计划 ( 社会发展 ) 项目 (BE2017692)；江苏大学临床医学科技发展基金项目 ( JLY20160009)。 |
摘要
非编码RNA(non-coding RNA，ncRNA)是一类由基因组序列转录形成，但不具备蛋白质合成功能的RNA。根据分子链长度不同，ncRNA可分为长链非编码RNA(long non-coding RNA，lncRNA；≥ 200 bp)和短链非编码RNA(shor t non-coding RNA；<200 bp)。其中，短链非编码RNA又分为微小RNA(microRNA，miRNA)、内源性小干扰RNA(small interfering RNA，siRNA)和PiRNA(PIWI-interfering RNA)等。目前发现多种miRNA和lncRNA在炎症性肠病患者肠黏膜组织和外周血细胞中表达异常，与肠黏膜炎症发生发展密切相关，为炎症性肠病临床诊断和靶向治疗研究提供了新的方向。
关键词：
微小RNA；非编码RNA；炎症性肠病；靶向治疗
Research progress of non-coding RNA in inflammatory bowel disease
CorrespondingAuthor: SHI Yan Email: sysh2014@126.com
DOI: 10.3978/j.issn.2095-6959.2018.09.028
Foundation: This work was supported by National Natural Science Foundation (81700494), Jiangsu Provincial Key Research and Development Program (BE2017692) and Clinical Medical Science and Technology Development Foundation of Jiangsu University ( JLY20160009)
Abstract
Non-coding RNA (ncRNA) is a group of RNA that is transcribed from genomic sequences but does not have any protein synthesis function. According to the length of the molecular chain, ncRNAs can be divided into long non-coding RNA (lncRNA, ≥200 bp) and short non-coding RNA (<200 bp). Short non-coding RNAs include microRNA (miRNA), endogenous small interfering RNA (siRNA), and PiRNA (PIWI-interfering RNA). Many miRNAs and lncRNAs have been found to be aberrant expressed in intestinal mucosa and peripheral blood cells in patients with inflammatory bowel disease (IBD), and are closely correlated with the development of intestinal mucosal inflammation. These findings provide new insights on the clinical diagnosis and targeted therapy of inflammatory bowel disease.
Keywords：
microRNA; long non-coding RNA; inflammatory bowel disease; targeted therapy