Objective: To investigate the post-traumatic growth of parents with idiopathic thrombocytopenic purpura and to explore the effect of personality traits on post-traumatic growth. Methods: A total of 108 parents whose children suffered from idiopathic thrombocytopenic purpura were enrolled in the General Information Questionnaire, Post-traumatic Growth Scale, and Eysenck Personality Questionnaire. Results: The total post-traumatic growth of children suffered from idiopathic thrombocytopenic purpura was 58.45±16.83. The endo-exogenous (P<0.001) was significantly positively correlated with the post-traumatic growth of parents. Psychoticism (P=0.007) and neuroticism (P=0.014) were significantly negatively correlated with post-traumatic growth of parents (P<0.05); personality traits (inside-outward P<0.001, psychotic P=0.007, neurotic P=0.014), gender (P<0.001), education level (P=0.038), marital status (P=0.007), condition classification (P=0.002) were special factors affecting post-traumatic growth of parents. Conclusion: The post-traumatic growth of parents is moderate. Personality traits, gender, education level, marital status and disease level are the influencing factors. Medical staff can take measures combined with active personality traits and parents’ general demographic characteristics to promote the growth of parents after trauma.