A 型肉毒毒素在神经系统疾病中的临床应用
| 作者: |
1,2张东亮,
1,2赵舒煊,
1,2王明,
1,2陈铁戈,
1张海鸿
1 兰州大学第二医院骨科，兰州 730030 2 甘肃省骨关节疾病研究重点实验室，兰州 730030 |
| 通讯: |
张海鸿
Email: zhanghaihong1968@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.07.030 |
| 基金: | 甘肃省自然科学基金(17JR5RA238)。 |
摘要
A型肉毒毒素(botulinum neurotoxin type A，BoNT/A)是一种嗜神经性的细菌外毒素，具有解痉和 镇痛作用，可多次使用，因而在神经系统相关的疾病中得到广泛应用。BoNT/A还参与调节降钙素 基因相关肽(calcitonin gene-related peptide，CGRP)、K+和P物质的释放，并具有潜在的抗有丝分裂 和抗肿瘤活性，这为扩大BoNT/A应用和研究提供了理论基础。本文就近年A型肉毒毒素在肌张力 障碍、痉挛、神经性病理性疼痛、自主神经失调、原发性头痛和脊髓损伤等神经系统相关疾病中 的应用以及研究综述，为A型肉毒毒素的运用和研究提供新视角、新指导。
关键词：
肉毒毒素；神经系统；综述
Clinical application of botulinum neurotoxin A in neurological diseases
CorrespondingAuthor: ZHANG Haihong Email: zhanghaihong1968@sina.com
DOI: 10.3978/j.issn.2095-6959.2018.07.030
Foundation: This work was supported by the Natural Science Foundation of Gansu Province, China (17JR5RA238).
Abstract
As a kind of neurotropic exotoxin, botulinum neurotoxin type A (BoNT/A) has a function of muscular paralysis and analgesic. BoNT/A can be widely used in nervous system-related diseases. It is also involved in regulating the release of calcitonin gene-related peptide (CGRP), K+ and substance P and has potential anti-mitotic and antitumor activity, which will be the basis for the expansion of BoNT/A application and research. The article reviewed the recent developments in clinical application and research of BoNT/A in nervous system-related diseases, such as dystonia,spasticity, neuropathic pain, autonomic dysfunction, primary headache and spinal cord injury, which will provide a new perspective and new guidance for application and research of BoNT/A.
Keywords：
botulinum neurotoxin type A; nervous system; review