文章摘要

P物质及其在病毒感染中的作用

作者: 1徐文雅, 2周洪伟
1 涟水县人民医院门诊部，江苏 淮安 223400
2 涟水县人民医院眼科，江苏 淮安 223400
通讯: 周洪伟 Email: zhouhongwei@sjtu.org
DOI: 10.3978/j.issn.2095-6959.2018.02.035
基金: 国家自然科学基金(81570820)。

摘要

P物质是一种重要的神经肽，其受体主要是神经激肽受体1(neurokinin receptors 1，NK1-R)。P物质在多种感染中发挥作用。P物质受体拮抗剂阿瑞吡坦有抗HIV-1的作用。利用宿主蛋白抗病毒的机制不依赖于病毒DNA聚合酶，减少了病毒耐药的可能。
关键词： P物质；神经激肽受体1；病毒感染

Substance P and its role in viral infection

Authors: 1XU Wenya, 2ZHOU Hongwei
1 Department of Outpatient, Lianshui County People’s Hospital, Huaian Jiangsu 223400, China
2 Department of Ophthalmology, Lianshui County People’s Hospital, Huaian Jiangsu 223400, China

CorrespondingAuthor: ZHOU Hongwei Email: zhouhongwei@sjtu.org

DOI: 10.3978/j.issn.2095-6959.2018.02.035

Foundation: This work was supported by National Natural Science Foundation of China (81570820).

Abstract

Substance P (SP) is an important neuropeptide, and its receptor is mainly neurokinin receptors 1 (NK1-R). SP plays a role in the process of multiple viral infections. Aprepitant, which is a SP receptor antagonist, has anti-HIV-1 effect. The anti-viral mechanism of host protein does not depend on the virus DNA polymerase, and thus reduces the possibility of drug resistance.
Keywords： substance P; neurokinin receptors 1; virus infection

文章选项

下载引文

分享