α受体阻滞剂在嗜铬细胞瘤和副神经节瘤围手术期的应用
| 作者: |
1王东明,
1王宏磊,
1倪少滨
1 哈尔滨医科大学附属第一临床医院泌尿外科二科，哈尔滨 150001 |
| 通讯: |
倪少滨
Email: nsb1960@aliyun.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.02.028 |
摘要
嗜铬细胞瘤和副神经节瘤(pheochromocytoma and paraganglioma，PPGL)的标准治疗方法是完整的手术切除，术中触碰肿瘤释放的大剂量儿茶酚胺(catecholamine，CA)可能导致危险性的血压升高和心律失常等。为提高手术安全性，术前准备中推荐做CA的药物阻断处理，临床中最常用的药物为α受体阻滞剂。
关键词：
嗜铬细胞瘤；α受体阻滞剂；围手术期
Application of alpha-adrenergic antagonists in perioperative of pheochromocytoma and paraganglioma
CorrespondingAuthor: NI Shaobin Email: nsb1960@aliyun.com
DOI: 10.3978/j.issn.2095-6959.2018.02.028
Abstract
The standard treatment of pheochromocytoma and paraganglioma (PPGL) is complete surgical resection, and unavoidable intraoperative manipulation of the tumour can result in release of high-dose catecholamine (CA), which may lead to dangerous hypertension and arrhythmia, etc. In order to improve the safety of surgery, preoperative alpha-blockade was recommended for patients undergoing PPGL resection, and the most commonly used drug in clinic was alpha-adrenergic antagonists. This paper reviews the application of alpha-adrenergic antagonists in the perioperative management of PPGL.
Keywords：
pheochromocytoma and paraganglioma; pheochromocytoma; preoperative preparation; α-blockade