创伤性颅脑损伤患者中降钙素原、CRP及D-二聚体的 临床检测意义
| 作者: |
1缪惠锴,
2王嘉妮,
2刘璐,
2肖立
1 南京医科大学附属无锡第二医院检验科，江苏 无锡 214002 2 解放军第101医院检验科，江苏 无锡 214044 |
| 通讯: |
缪惠锴
Email: miaohuikai1989@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.01.007 |
摘要
目的：研究创伤性颅脑损伤(traumatic brain injury，TBI)患者中降钙素原(procalcitonin，PCT)，CRP，D-二聚体水平与患者病情程度及临床预后中的价值。方法：分析2014年1月至2016年12月接受治疗的250例TBI患者，采用格拉斯哥昏迷评分法(Glasgow Coma Scale，GCS)评估病情，电化学发光法及免疫散射比浊法检测患者血清中PCT，CRP和D-二聚体水平，分析其与患者病情的相关性，Cox回归模型探讨与患者死亡的关系。结果：TBI患者中PCT，CRP，D-二聚体水平随着病变的严重程度增加明显升高，差异具有统计学意义(P<0.05)；存活组GCS评分显著高于死亡组(P<0.01)，而PCT，CRP及D-二聚体水平均显著低于死亡组(P<0.01)；多因素分析提示GCS评分，PCT，CRP以及D-二聚体是TBI患者死亡的独立因素；PCT，CRP，D-二聚体水平与患者入院时GCS评分存在负相关，相关系数分别为–0.23，–0.32，–0.42(均P<0.05)。结论：PCT，CRP，D-二聚体水平与TBI患者的损伤程度及预后具有明显相关性。
关键词：
降钙素原；CRP；D-二聚体；创伤性颅脑损伤
Clinical detection significance of procalcitonin, CRP and D-dimer in traumatic brain injury patients
CorrespondingAuthor: MIAO Huikai Email: miaohuikai1989@163.com
DOI: 10.3978/j.issn.2095-6959.2018.01.007
Abstract
Objective: To analyze the effects of procalcitonin (PCT), CRP, D-dimer on the severity and clinical prognosis of patients with traumatic brain injury (TBI). Methods: A total of 250 TBI patients were recruited from January 2014 to December 2016, and the disease severity was assessed by Glasgow Coma Scale (GCS) score. Levels of PCT, CRP and D-dimer were detected and their co-relationship with patient’s condition and death rate were investigated, and the Cox review model was used to explore the relationship with the patient’s death. Results: Level of PCT, CRP and D-dimer in TBI patients increased significantly with the severity of the lesion; the level of GCS score of patients in the survival group elevated significantly when compared with that in the death group, whereas the levels of PCT, CRP and D-dimer in the survival group decreased significantly. Multivariate analysis indicated that PCT, CRP, D-dimer and GCS score were independent risk factors for death in TBI patients. The levels of PCT, CRP and D-dimer were positive with GCS (r=‒0.23, ‒0.32, ‒0.42; P<0.05). Conclusion: Level of PCT, CRP and D-dimer closely associated with the severity and prognosis of TBI patients.
Keywords：
procalcitonin; C reaction protein; D-dimer; traumatic brain injury