文章摘要

泰州市人民医院2016年血培养阳性病原菌的分布及其耐药性

作者: 1徐 娟, 1陆 桃红, 1张 庆芳, 1周 成林, 2顾 兵
1 泰州市人民医院检验科,江苏 泰州 225300
2 徐州医科大学医学技术学院,江苏 徐州 221000
通讯: 周 成林 Email: 18762340015@126.com
DOI: 10.3978/j.issn.2095-6959.2017.12.024

摘要

目的:了解泰州市人民医院2016年血培养病原菌的分布和耐药情况。方法:采用BACTEC ALERT 3D全自动血培养仪进行血培养;采用VITEK 2 Compact全自动鉴定系统进行微生物鉴定及药敏试验,链球菌药敏为纸片扩散法(K-B法),真菌药敏采用DL-96 FUNGUS;WHONET5.6软件进行统计分析。结果:2016年全年血培养共检出病原菌380株,排列前5位的菌种依次为大肠埃希菌(24.2%)、表皮葡萄球菌(14.7%)、人葡萄球菌(12.1%)、肺炎克雷伯菌(8.7%)、金黄色葡萄球菌(7.9%)。血培养病原菌主要分布于:新生儿ICU(newborn-intensive care unit,NICU)、感染科、ICU、消化科。大肠埃希菌和肺炎克雷伯菌超广谱β-内酰胺酶(extended spectrum β lactamases,ESBLs)检出率分别为53.3%,33.3%。耐甲氧西林金黄色葡萄球菌(methicillin resistant Staphylococcus aureus,MRSA)检出率为44.4%,葡萄球菌未发现对利奈唑胺、万古霉素、奎奴普丁/达福普汀、替加环素耐药的菌株。结论:血培养病原菌在不同科室的分布和耐药性不同。
关键词: 血培养;病原菌分布;耐药率

Distribution and resistance of pathogens isolated from blood culture of Taizhou People’s Hospital in 2016

Authors: 1XU Juan, 1LU Taohong, 1ZHANG Qingfang, 1ZHOU Chenglin, 2,3GU Bing
1 Department of Laboratory, Taizhou People’s Hospital, Taizhou Jiangsu 225300, China
2 College of Medical Technology,
3 Xuzhou Medical University, Xuzhou Jiangsu 221000, China

CorrespondingAuthor:ZHOU Chenglin
Email: 18762340015@126.com

Abstract

Objective: To investigate the distribution and resistance of pathogens isolated from blood culture of patients in the Jiangsu Taizhou People’s Hospital in 2016. Methods: All blood samples were cultured by BACTEC ALERT 3D. Automatic detection machine of VITEK-2 Compact was used for identification of bacteria and fungus, as well as the susceptibility of non-fastidious bacteria. Susceptibility of streptococcus was tested by K-B method while susceptibility of fungus was tested by DL-96 FUNGUS. WHONET5.6 software was used for statistical analysis. Results: The total of pathogen strains isolated from blood culture in 2016 was 380. The top five bacteria were Escherichia coli (24.2%), Staphylococcus epidermidis (14.7%), Staphylococcus hominis (12.1%), Klebsiella pneumonia (8.7%), Streptococcus (7.9%). The pathogens of blood culture were mainly isolated from the department of newborn-intensive care unit (NICU), infection, ICU, gastroenterology dept. The resistance rates of Escherichia coli and Klebsiella pneumonia to extended spectrumβ lactamases (ESBLs) were 53.3%, 33.3%. Staphylococcus aureus had a 44.4% resistance rate to methicillin, while all of the three aureus were sensitive to linezolid, vancomycin, quinupristin/Dafoe leptin, tigecycline. Conclusion: Diversities of distribution and antimicrobial susceptibility of blood culture isolates are found in different clinical departments.
Keywords: blood culture; the distribution of pathogens; drug resistance rate

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