文章摘要

膀胱癌组织中HSPC238的表达及其临床意义

作者: 1卢 志承, 1符 志龙, 1陈 世梁, 1吴 文川
1 海南省人民医院病理科,海口 570311
通讯: 卢 志承 Email: 21243762@qq.com
DOI: 10.3978/j.issn.2095-6959.2017.12.021

摘要

目的:检测膀胱癌患者肿瘤组织中HSPC238的改变,并探讨其相关的临床意义。方法:取海南省人民医院2016年1月至2017年7月收治的膀胱癌116例,取癌旁非肿瘤组织作为对照。使用荧光定量PCR检测HSPC238基因的表达。结果:膀胱癌组织中HSPC238为0.172±0.023,显著低于对照膀胱组织的0.304±0.051(P<0.01)。HSPC238在TNM临床III,IV期患者为0.137±0.017,显著低于I,II期患者的0.194±0.028(P<0.01)。HSPC238在浸润深度达到肌层的患者为0.161±0.021,显著低于未达到肌层的0.195±0.029(P<0.05)。HSPC238在中、低分化患者为0.156±0.021,显著低于高分化的0.205±0.037(P<0.05)。HSPC238在淋巴结有转移患者为0.147±0.016,显著低于无转移的0.181±0.022(P<0.05)。结论:膀胱癌组织中HSPC238基因低表达,其表达变化可能参与膀胱癌的发生、发展、侵袭和转移。
关键词: 膀胱癌;HSPC238基因;荧光定量-PCR

HSPC238 mRNA expression in bladder cancer and its clinical significance

Authors: 1LU Zhicheng, 1FU Zhilong, 1CHEN Shiliang, 1WU Wenchuan
1 Department of Pathology, Hainan People’s Hospital, Haikou 570311, China

CorrespondingAuthor:LU Zhicheng Email: 21243762@qq.com

Abstract

Objective: To detect HSPC238 mRNA expression in bladder cancer and explore its clinical significance. Methods: A total of 116 patients of bladder cancer were enrolled in this study. The non-cancerous tissues beside the tumor were taken as controls. Real-time PCR analysis was used to detect HSPC238 mRNA expression. Results: HSPC238 in bladder cancer tissue was 0.172±0.023, which was lower than that of 0.304±0.051 in control tissue (P<0.01). HSPC238 in III and IV stage group was 0.137±0.017, which was lower than that of 0.194±0.028 in I and II stage group (P<0.01). HSPC238 of patients with muscular layer infiltration was 0.161±0.021, which was lower than that of 0.195±0.029 in non-muscular layer infiltration patients (P<0.05). HSPC238 in median and low differentiation group was 0.156±0.021, which was lower than that of 0.205±0.037 in well differentiation group (P<0.05). HSPC238 in lymph node metastasis group was 0.147±0.016, which was lower than that of 0.181±0.022 in non-lymph node metastasis group (P<0.05). Conclusion: Low expression of HSPC238 was detected in bladder cancer, which was related to clinical stages, lymph node metastasis, and tumor differentiation of bladder cancer.
Keywords: bladder cancer; HSPC238 gene; real-time PCR analysis