文章摘要

肺腺样囊性癌的分子特征

作者: 1何诚, 1黄榕芳, 1刘伟, 2庄武, 3方美玉, 2吴标, 2郑晓彬, 1许春伟, 1陈燕坪, 1陈刚
1 福建医科大学附属福建省肿瘤医院病理科，福州 350014
2 福建医科大学附属福建省肿瘤医院胸部肿瘤内科，福州 350014
3 浙江省肿瘤医院综合内科，杭州 310022
通讯: 吴标 Email: wubiao97@qq.com
DOI: 10.3978/j.issn.2095-6959.2017.11.011

摘要

目的：探讨肺腺样囊性癌的分子特征。方法：对2007年7月至2016年12月15例病理确诊的肺腺样囊性癌临床特征和分子特点进行回顾性分析。结果：EGFR基因突变率为6.67%(1/15)，且为19del， EGFR基因状态与性别(P=1.000)、年龄(P=1.000)、吸烟状态(P=1.000)及分期(P=1.000)均无相关性；未见ALK融合基因和ROS1融合基因。结论：肺腺样囊性癌中存在常见基因改变，常规基因检测仍不可忽视。
关键词： 腺样囊性癌 分子特征 基因检测

Molecular features of pulmonary adenoid cystic carcinoma

Authors: 1He Cheng, 1Huang Rongfang, 1Liu Wei, 2Zhuang Wu, 3Fang Meiyu, 2Wu Biao, 2Zheng Xiaobin, 1Xu Chunwei, 1Chen Yanping, 1Chen Gang
1 Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014
2 Department of Medical Thoracic Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014
3 Department of Comprehensive Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China)

CorrespondingAuthor: Wu Biao Email: wubiao97@qq.com

DOI: 10.3978/j.issn.2095-6959.2017.11.011

Abstract

Objective: To investigate the molecular characteristics of pulmonary adenoid cystic carcinoma (PACC). Methods: From July 2013 to December 2016, 15 PACC patients received treatment. All the patients were diagnosed by pathology. We retrospectively reviewed the clinical data and genetic state. Results: EGFR mutation rate was 6.67% (1/15), and it was 19del, the relationship between EGFR gene status and gender (P=1.000), age (P=1.000), smoking status (P=1.000) and stage (P=1.000) were no significant, and ALK fusion and ROS1 fusion gene was not detected. Conclusion: Gene change exists PACC, and the gene detection cannot be ignored in PACC.
Keywords： adenoid cystic carcinoma molecular features gene detection

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