文章摘要

腹膜胶质瘤病临床病理分析

作者: 1冯会敏, 2孙洋, 3杨迷玲, 4廉世萍, 5吴焕文
1 衡水市第二人民医院病理科，河北 衡水 053000
2 中国医学科学院阜外医院试验诊断中心，北京 100037
3 郑州市人民医院病理科，郑州 450000
4 呼伦贝尔市中蒙医院病理科，内蒙古 呼伦贝尔 021000
5 中国医学科学院北京协和医院病理科，北京 100032
通讯: 吴焕文 Email: whw14093@163.com
DOI: 10.3978/j.issn.2095-6959.2017.10.019

摘要

目的：探讨腹膜胶质瘤病(gliomatosis peritonei，GP)的临床病理特征。方法：观察和分析15例GP患者的临床病理学特征，并复习相关文献。结果：15例GP患者，年龄6~28(中位22)岁；合并卵巢未成熟畸胎瘤12例，成熟畸胎瘤2例,混合性生殖细胞瘤1例；15例中8例与原发瘤同时发现，7例二次手术时发现。随访5~148个月，至随访终点，15例中有4例复发或进展；GP是否复发或进展与原发瘤破裂/粘连有显著相关性(χ2=2.47，P=0.03)，与患者年龄、化疗与否、是否妊娠、淋巴结有无转移、原发肿瘤大小、原发肿瘤是否成熟、原发瘤未成熟成分分级、GP自身大小均无统计学意义(P>0.05)。结论：GP非常罕见，主要发生于卵巢未成熟畸胎瘤，有着独特的临床病理学特征，当原发瘤破裂/粘连时，复发或进展概率增高，须长期随访。
关键词： 腹膜胶质瘤病 卵巢畸胎瘤 临床病理特征 预后

Clinicopathologic features of gliomatosis peritonei

Authors: 1FENG Huimin, 2SUN Yang, 3YANG Miling, 4LIAN Shiping, 5WU Huanwen
1 Department of Pathology, People’s Hospital of Hengshui, Hengshui Hebei 053000
2 State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037
3 Department of Pathology, People’s Hospital of Zhengzhou, Zhengzhou 450000
4 Department of Pathology, Zhongmeng Hospital of Hulunbeier, Hulunbeier Neimenggu 021000
5 Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100032, China

CorrespondingAuthor: WU Huanwen Email: whw14093@163.com

DOI: 10.3978/j.issn.2095-6959.2017.10.019

Abstract

Objective: To elucidate the pathological and clinical features of gliomatosis peritonei (GP). Methods: Fifteen cases of GP were obtained from Peking Union Medical College Hospital (PUMCH). The clinical and pathological findings were analyzed with a review of literature. Results: Fifteen patients aged 6–28 (median, 22) years. The primary ovarian tumors consisted of immature teratoma (n=12) and mature teratoma (n=2). GP was discovered with the primary tumor in 8 patients and at a secondary surgery in 7 patients. Follow-up data were available for 15 patients with a follow-up time of 5–148 months. Recurrence or progression were found in 4 of 15 patients (26.7%). We found that recurrence or progression was correlated with primary tumor rupture or adhesion (χ2=2.47, P=0.03), but not correlated with age, chemotherapy, pregnancy, lymphatic metastasis, primary tumor size, primary tumor maturity, grade of primary tumor (P>0.05). Conclusion: GP is rare, and often associated with ovarian teratoma. Owing to the risk of recurrence and malignant transformation of GP, a long-term follow-up is necessary, especially for those with primary tumor rupture or adhesion.
Keywords： gliomatosis peritonei ovarian teratoma clinicopathologic features Prognosis

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