子宫内膜样腺癌中Stathmin和Ki-67的表达及意义
| 作者: |
1熊中堂,
1江庆萍,
1刘少颜,
2丘福满
1 广州医科大学附属第三医院病理科，广州 510150 2 广州医科大学公共卫生学院化学致癌研究所，广州 511436 |
| 通讯: |
丘福满
Email: fumanqiu@gzhmu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2017.07.006 |
| 基金: | 国家自然科学基金, 81602289 广州市科技计划项目, 201707010123 |
摘要
目的：研究Stathmin和Ki-67在子宫内膜样腺癌和正常子宫内膜中的表达差异，探讨Stathmin和Ki-67在子宫内膜样腺癌发生发展过程中的意义。方法：采用免疫组织化学法检测99例子宫内膜样腺癌及67例正常子宫内膜中Stathmin 和Ki-67的表达情况。结果：子宫内膜样腺癌中Stathmin和Ki-67表达率分别为75.8%，70.7%，显著高于正常子宫内膜中的9.0%，4.5%，差异有统计学意义(P<0.05)；Stathmin和Ki-67表达与子宫内膜样腺癌组织学分级相关(P<0.05)，与患者年龄、临床分期、浸润深度、淋巴结转移及脉管侵犯无关(P>0.05)；Stathmin表达和Ki-67表达呈正相关(r=0.672，P<0.05)。结论：子宫内膜样腺癌中Stathmin和Ki-67高表达可能共同参与子宫内膜样腺癌发生和分化；Stathmin和Ki-67表达呈正相关，提示Stathmin高表达可能与子宫内膜样腺癌高增殖性相关。
关键词：
子宫内膜样腺癌
Stathmin
Ki-67
免疫组织化学
Expression and significance of stathmin and Ki-67 in endometrioid adenocarcinoma
CorrespondingAuthor: QIU Fuman Email: fumanqiu@gzhmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2017.07.006
Abstract
Objective: To investigate the expression of Stathmin and Ki-67 in endometrioid adenocarcinoma and its significance. Methods: Immunohistochemical staining for Stathmin and Ki-67 was performed in 99 cases of endometrioid adenocarcinoma and 67 cases of normal endometrium. Results: The expression rates of Stathmin and Ki-67 in endometrioid adenocarcinoma were 75.8% and 70.7%, respectively. The high expression rates of Stathmin and Ki-67 in normal endometrioma were 9.0% and 4.5%, respectively. The difference between endometrioid adenocarcinoma and normal endometrioma was significant (P<0.05). The expression of Stathmin and Ki-67 in endometrioid adenocarcinoma was related with its histology grading (P<0.05), but was not related with patients' age, clinical stage, invasion depth, lymph node metastasis and vascular invasion (P>0.05). The expression of Stathmin and Ki-67 were significantly positively correlated (r=0.672, P<0.05). Conclusion: The occurrence and differentiation of endometrial adenocarcinoma may be ralated with the high expressions of Stathmin and Ki-67. The expression of Stathmin and Ki-67 were significantly positively correlated indicated that the high expression of Stathmin may be associated with higher proliferation of the endometrial adenocarcinoma.