肺黏液表皮样癌的分子特征
| 作者: |
1庄武,
2王文娴,
3林雪平,
1黄韵坚,
4许春伟,
4陈燕坪,
5方美玉,
6朱有才,
7陆燕,
4陈刚
1 福建医科大学附属福建省肿瘤医院胸部肿瘤内科，福州 350014 2 浙江省肿瘤医院胸部肿瘤内科，杭州 310022 3 浙江省荣军医院病理科，浙江 嘉兴 314000 4 福建医科大学附属福建省肿瘤医院病理科，福州 350014 5 浙江省肿瘤医院综合肿瘤内科，杭州 310022 6 浙江省荣军医院胸部疾病诊疗中心，浙江 嘉兴 314000 7 嘉兴市第二医院内科，浙江 嘉兴 314000 |
| 通讯: |
王文娴
Email: helen-0407@163.com 黄韵坚 Email: 13805099580@126.com 许春伟 Email: xuchunweibbb@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.07.010 |
| 基金: | 国家临床重点专科建设项目, 2013 福建省科技厅引导性项目, 2016Y0019 福建省科技厅引导性项目, 2015Y0011 浙江省卫生科研计划基金, 2013KYB051 浙江省中医药局科研基金, 2013ZQ005 浙江省科技厅公益类科研计划, 2015C33194 吴阶平医学基金会临床科研资金项目, 20114272111 嘉兴市科技计划项目, 2016AY23087 嘉兴市科技局项目, 2014AY21031-6 |
摘要
目的：探讨肺黏液表皮样癌的分子特征。方法：回顾性对2013年7月至2016年12月13例病理确诊并接受治疗的肺黏液表皮样癌临床特征和分子特点进行分析。结果：EGFR基因突变率为15.38%(2/13)，且2例均为L861Q点突变，EGFR基因状态与性别(P=1.000)、年龄(P=1.000)、吸烟史(P=0.848)及分期(P=1.000)均无相关性；MAML2融合基因阳性率为45.45%(5/11)，MAML2融合基因状态与性别(P=0.521)、年龄(P=0.521)、吸烟史(P=1.000)及分期(P=0.924)均无相关性(P>0.05)。结论：肺黏液表皮样癌中EGFR基因最常见的突变为L861Q，EGFR基因野生型患者中存在MALM2基因融合。
关键词：
肺黏液表皮样癌
分子特征
EGFR基因
MAML2基因
Molecular features of pulmonary mucoepidermoid carcinoma
CorrespondingAuthor: WANG Wenxian Email: helen-0407@163.com
DOI: 10.3978/j.issn.2095-6959.2017.07.010
Abstract
Objective: To investigate the molecular characteristics of pulmonary mucoepidermoid carcinoma (PMEC). Methods: From July 2013 to December 2016, 13 PMEC patients received treatment. All the patients were diagnosed by pathology. We retrospectively reviewed the clinical data and genetic state. Results: EGFR mutation rate was 15.38% (2/13), and 2 cases were both L861Q point mutations, the relationship between EGFR gene status and gender (P=1.000), age (P=1.000), smoking (P=0.848) and stage (P=1.000) were no significant; the positive rate of MAML2 fusion gene was 45.45% (5/11). the relationship between MAML2 fusion gene status and gender (P=0.521), age (P=0.521), smoking (P=1.000) and stage(P=0.924) were all no significant. Conclusion: The most common form change of pulmonary mucoepidermoid carcinoma was EGFR gene L861Q point mutation, MALM2 fusion gene exist in the EGFR gene wild type patients.