EGFR和Ki-67在肠癌组织中的表达及临床意义
| 作者: |
1邵好青,
1雷久士
1 湖南中医药大学医学院，长沙 410208 |
| 通讯: |
雷久士
Email: 1109qing@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.04.007 |
| 基金: | 湖南省科技厅计划项目, 2012FJ3095 湖南省重点学科–中西结合基础 |
摘要
目的：探讨表皮生长因子受体(epidermal growth factor receptor，EGFR)和Ki-67在结直肠癌(colorectal cancer，CRC)组织中的表达及临床意义。方法：应用免疫组织化学染色检测100例CRC组织中EGFR和Ki-67蛋白的表达，并分析其与临床病理特征的关系。结果：EGFR，Ki-67在CRC中的阳性表达率分别为70.0%，85.0%。EGFR的阳性表达在结直肠癌的不同分化程度和TNM分期中差异有统计学意义(P<0.05)，与淋巴结转移呈正相关(P<0.05)。Ki-67的表达与结直肠癌组织分化程度、淋巴结转移和肿瘤原发部位有关(P<0.05)。在CRC组织中，Ki-67与EGFR蛋白呈显著正相关(r=0.581，P<0.001)。结论：EGFR和Ki-67蛋白的表达与组织分化程度及淋巴结转移密切相关，二者的联合检测有助于结直肠癌恶性程度的判断和预后的估计。
关键词：
结直肠癌
免疫组织化学
表皮生长因子受体
Ki-67
Expression and significance of EGFR and Ki-67 proteins in carcinoma of colon and rectum
CorrespondingAuthor: LEI Jiushi Email: 1109qing@sina.com
DOI: 10.3978/j.issn.2095-6959.2017.04.007
Abstract
Objective: To investigate the expression of epidermal growth factor receptor (EGFR) and Ki-67 proteins in colorectal cancer (CRC) and their clinical significance. Methods: The expression of EGFR and Ki-67 proteins was detected by immunohistochemical staining in 100 cases of CRC. Results: The positive rates of EGFR and Ki-67 proteins’ expression were 70.0% and 85% in CRC. In CRC, EGFR expression level was associated with differentiation, TNM stage and lymph node metastasis (P<0.05). The expression of Ki-67 protein was related to differentiation, lymph node metastasis and primary tumor site (P<0.05). In addition, there was a significantly positive correlation between the expression of Ki-67 and EGFR in CRC (r=0.581, P<0.001). Conclusion: The expression of EGFR and Ki-67 protein are reversely related to differentiation and lymph node metastasis .Thus, a combined detection of both EGFR and Ki-67 protein might be valuable in evaluating the degree of malignant and estimating prognostic in CRC.