文章摘要

NOD1和NOD2与炎性肠病

作者: 1王雪纯, 2薛丽英
1 河北医科大学口腔医学院，石家庄 050011
2 河北医科大学病理学研究室，石家庄 050011
通讯: 薛丽英 Email: xueliying123@163.com
DOI: 10.3978/j.issn.2095-6959.2017.05.031

摘要

NOD1和NOD2蛋白是一类新型胞浆内模式识别受体，在宿主固有免疫和自噬过程中起着关键的作用，对维持肠道微生态和黏膜屏障作用至关重要，研究表明NOD1和NOD2基因多态性和表达异常与炎性肠病的发生密切有关。
关键词： 核苷酸结合寡聚化结构域蛋白 固有免疫 自噬 炎性肠病 遗传易感基因

NOD1 and NOD2 proteins in inflammatory bowel diseases

Authors: 1WANG Xuechun, 2XUE Liying
1 College of Stomatology, Hebei Medical University, Shijiazhuang 050011
2 Department of Pathology, Hebei Medical University, Shijiazhuang 050011, China

CorrespondingAuthor: XUE Liying Email: xueliying123@163.com

DOI: 10.3978/j.issn.2095-6959.2017.05.031

Abstract

NOD1 and NOD2 proteins are new types of intracellular pattern recognition receptors, which play an important role in innate immune response, autophagy process, regulating intestinal homeostasis and maintaining the gut mucosal barrier. Recent studies demonstrated that NOD1 and NOD2 gene polymorphisms and abnormal expression are closely related to the pathological mechanisms of inflammatory bowel disease.

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