Objective: To assess the efficacy of “doctor-nurse integration” special management in the promotion of early exercise in patients after underwent percutaneous nephrostolithotomy (PCNL). Methods: A “doctor-nurse integration” specific management team was established. The team formulated process for “doctor-nurse integration” exercise management after operation. The reasons for the increase of postoperative in-bed time in patients after PCNL were analyzed and the strategies were proposed in the management team. The surgeons and nurses were trained to clarify their own responsibility in the team by co-operation, co-supervision and feedback. The postoperative in-bed time, anal exhaust time, postoperative hospital stay and satisfactory degree were compared in patients after PCNL between the control group given conventional nursing and the observation group given “doctor-nurse integration” specific management. Results: The postoperative in-bed time, anal exhaust time and postoperative hospital stay of the observation group were significantly decreased and satisfactory degree was elevated compared to the control group. Conclusion: “Doctor-nurse integration” special management can promote postoperative early mobilization, reduce postoperative hospital stay and improve satisfactory degree in patients after PCNL.