文章摘要

Sirt1在呼吸系统疾病中的研究进展

作者: 1,2郑成功, 1,2胡瑞成, 1戴爱国
1 南华大学附属省马王堆医院呼吸内科，长沙 410016
2 湖南省人民医院呼吸内科，长沙 410016
通讯: 胡瑞成 Email: huruicheng@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2017.04.030
基金: 国家自然科学基金, 81070035 湖南省科技计划, 2009JT3054 湖南省卫生厅科研基金, B2008-026

摘要

沉默信息调节因子2相关酶1(silent information regulator 2 homolog 1，Sirt1)在生物体中广泛表达，属于第III类组蛋白去乙酰化酶(histone deacetylase，HDAC)。它可通过氧化应激、炎症、内质网应激(endoplasmic reticulum stress，ERS)等机制影响细胞的凋亡和衰老，广泛参与多种疾病的发生与发展。
关键词： 沉默信息调节因子2相关酶1 氧化应激 炎症 内质网应激 慢性阻塞性肺疾病 支气管哮喘 肺癌

Research progress of Sirt1 in the respiratory diseases

Authors: 1,2ZHENG Chenggong, 1,2HU Ruicheng, 1DAI Aiguo
1 Department of Respiratory, Provincial Mawangdui Hospital Affiliated to University of South China, Changsha 410016
2 Department of Respiratory, Hunan Province People's Hospital, Changsha 410016, China

CorrespondingAuthor: HU Ruicheng Email: huruicheng@hotmail.com

DOI: 10.3978/j.issn.2095-6959.2017.04.030

Abstract

The Silent information regulator 2 related enzymes 1 (Sirt1) is widely expressed in organisms, which belongs to class III histone deacetylase (histone deacetylase, HDAC). It can affect cell apoptosis and senescence through oxidative stress, inflammation and endoplasmic reticulum stress, widely involved in the occurrence and development of various diseases.

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