Hippo signaling pathway is an important signaling pathway that regulates organ growth and tissue size, which has been received much concern recently and shown to play an important role in the development and progression of tumors. For now, researches about the relationship of Hippo signaling pathway and kidney diseases are still at the initial stage. In acute renal injury, Hippo signaling pathway may be involved in the apoptosis of tubule epithelial cells, epithelial-mesenchymal transition (EMT) and acute renal injury (AKI) progress to chronic kidney disease (CKD) and other processes. In addition, Hippo signaling pathway is also involved in the development and progression of a variety of chronic kidney diseases, including focal segmental glomerulosclerosis, diabetic nephropathy, polycystic kidney disease. Therefore, this review will briefly summarize the researches progress about Hippo signaling pathway in the field of kidney diseases, so as to provide new insights and strategies for the prevention and treatment of kidney diseases.